Department of Analytical Chemistry, Razi University, Kermanshah, Iran
10.22126/anc.2021.6694.1028
Abstract
The electrochemical oxidation of an antidepressants drug, trazodon (TRZ) on the modified titanium dioxide–carboxylated multiwall carbon nanotube glassy carbon electrode (TiO2-cMWCNTs/GCE) was studied. The TiO2-cMWCNTs/GCE sensor was characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The influence of the effective parameters on the electrochemical behavior of TRZ such as: pH, modifier volume, accumulation potential and time were optimized. Under the optimized conditions, the proposed sensor was applied to determine TRZ in the ranges of 6–100 nM and 100-1000 nM with the detection limit of 5 nM using differential pulse anodic stripping voltammetry (DPASV) at neutral pH. The modified electrode exhibited a good sensitivity, stability and pleasant reproducibility, which was also applied for the determination of TRZ in the spiked human serum and pharmaceutical formulations, with satisfactory results.
Gholivand, M. B., & Godini, Z. (2021). Trace-level determination of trazodone with electrochemical sensor based on TiO2-cMWCNTs nanocomposite. Advances in Nanochemistry, 3(2), 88-96. doi: 10.22126/anc.2021.6694.1028
MLA
Mohammad Bagher Gholivand; Zahra Godini. "Trace-level determination of trazodone with electrochemical sensor based on TiO2-cMWCNTs nanocomposite". Advances in Nanochemistry, 3, 2, 2021, 88-96. doi: 10.22126/anc.2021.6694.1028
HARVARD
Gholivand, M. B., Godini, Z. (2021). 'Trace-level determination of trazodone with electrochemical sensor based on TiO2-cMWCNTs nanocomposite', Advances in Nanochemistry, 3(2), pp. 88-96. doi: 10.22126/anc.2021.6694.1028
VANCOUVER
Gholivand, M. B., Godini, Z. Trace-level determination of trazodone with electrochemical sensor based on TiO2-cMWCNTs nanocomposite. Advances in Nanochemistry, 2021; 3(2): 88-96. doi: 10.22126/anc.2021.6694.1028
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