Incorporating ZnFe2O4 nanoparticles and β-cyclodextrin into carbon paste electrode as a sensitive methyldopa electrochemical sensor

Document Type : Original Article

Authors

1 Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran

2 Department of Physics and Chemistry, Faculty of Basic Sciences, Imam Ali Military University, Tehran, Iran

10.22126/anc.2021.6533.1025

Abstract

A new electrochemical sensor for antihypertensive drug methyldopa (MDop) was prepared from a carbon paste electrode modified by hydrothermally synthesized ZnFe2O4 nanoparticles and β-cyclodextrin as a supermolecule. ZnFe2O4 nanoparticles were charectrized using scanning electron microscopy (SEM) and infrared spectroscopy. Comparison of unmodified electrode with electrodes modified by ZnFe2O4 and β-cyclodextrin and their nanocomposite showed that MDop had a higher oxidation current at the modified electrode by composite than each other electrodes at pH = 7. Moreover, the oxidation potential is lower than other electrodes at this pH. The modified electrode can measure MDop in the concentration range of 1-100 μM with a detection limit of 0.3 μM. The proposed sensor shows good repeatability and selectivity. It is also able to measure MDop in the blood serum sample.

Graphical Abstract

Incorporating ZnFe2O4 nanoparticles and β-cyclodextrin into carbon paste electrode as a sensitive methyldopa electrochemical sensor

Keywords

Advances in Nanochemistry
Volume 3, Issue 1
September 2021
Pages 10-15

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History

  • Receive Date: 01 June 2021
  • Revise Date: 12 July 2021
  • Accept Date: 29 July 2021

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